Nitrofurantoin 100mg MR (Modified-Release) Capsules are an antibiotic medication commonly used for the treatment of urinary tract infections (UTIs), specifically for cystitis.
- Mechanism of Action: Nitrofurantoin works by inhibiting bacterial enzymes, interfering with their ability to synthesize DNA, RNA, and cell wall components. This disrupts the growth and reproduction of bacteria, leading to their death.
- Administration: Nitrofurantoin 100mg MR is available in capsule form and is taken orally. The capsules are modified-release, which means they release the medication slowly over time, allowing for sustained therapeutic levels in the urinary tract.
- Indications: Nitrofurantoin 100mg MR is primarily used for the treatment and prevention of lower urinary tract infections, including uncomplicated cystitis caused by susceptible bacteria. It is not recommended for the treatment of upper urinary tract infections or kidney infections.
- Dosage: The usual dosage for Nitrofurantoin 100mg MR is one capsule taken twice daily with food or milk to enhance absorption. The duration of treatment is typically between 3 and 7 days, as determined by the healthcare provider based on the severity of the infection and individual patient factors.
- Adverse Effects: Common side effects of Nitrofurantoin may include nausea, vomiting, diarrhea, loss of appetite, and mild gastrointestinal disturbances. In some cases, it can cause more serious adverse effects, such as pulmonary toxicity or hepatotoxicity. It is important to report any unusual or severe side effects to a healthcare professional.
- Precautions and Contraindications: Nitrofurantoin may not be suitable for individuals with certain medical conditions, including severe kidney disease, glucose-6-phosphate dehydrogenase deficiency, or a history of hypersensitivity to nitrofurantoin. It should be used with caution in patients with liver disease. Pregnant women near term (38-42 weeks gestation) or during labor and delivery should avoid Nitrofurantoin due to the risk of neonatal hemolytic anemia.
- Drug Interactions: Nitrofurantoin may interact with other medications, such as antacids containing magnesium trisilicate, which can reduce the absorption of the antibiotic. It is important to inform the healthcare provider about all the medications, supplements, and herbal products you are taking.
- Resistance: Like other antibiotics, there is a potential for bacterial resistance to Nitrofurantoin. It is crucial to complete the full course of treatment as prescribed by the healthcare provider to minimize the risk of antibiotic resistance.
- It is important to note that the information provided here is a general overview and should not replace professional medical advice. If you have specific questions or concerns about Nitrofurantoin 100mg MR or its use for your condition, it is best to consult with a healthcare professional or pharmacist.